Ion homeostasis and apoptosis
WebApoptosis is a very important factor in an organism’s development, especially at the embryonic stage and in normal renewing tissue homeostasis (for example in epithelial and red or white blood cells) 2. On the other hand the same mechanism is activated in pathophysiological conditions such as neuronal or cardiac ischemia (see for example3). Web17 apr. 2006 · Ionic homeostasis and generation of plasma membrane potential (PMP) in the cells. The electrical gradient in the cells or PMP at rest arises mainly from two physiological parameters: 1) the presence of large gradients for K + and Na + across the plasma membrane; and 2) the relative permeability of the plasma membrane to those …
Ion homeostasis and apoptosis
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Web14 apr. 2024 · BackgroundAs a common cancer with high incidence rate and mortality, colorectal cancer (CRC) is seriously threatening human health. S-nitrosylation (SNO) proteins mediated by nitric oxide (NO) has important implications in the genesis, progression, and apoptosis of CRC. It’s worth noting that the SNO proteins also play an … Web27 jan. 2014 · Figure 2. Mitochondrial ion channels and their main proposed roles in cell death regulation in cancer cells. Ion channels involved in the regulation of mitochondrial …
Web13 apr. 2024 · Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of … WebAlterations in the transmembrane gradients of several physiological ions may influence programmed cell death. In particular, recent data suggest that increases in intracellular …
Web30 jan. 2024 · We thus conclude that ion influx is the likely cause of apoptosis, rather than apoptosis leading to changes in ion flux, as might be expected if 3, 5 and 6 were … Web9 aug. 2024 · Disruption of ion homeostasis contributes to apoptosis in HBE cells following PM exposure. a Chord diagram of ion homeostasis GO terms and involved genes in 500 μg/mL PM-exposed HBE cells. b Heatmap of ion homeostasis-related genes in HBE cells following PM exposure for 24 h by microarray.
WebWe aim to develop pharmacological therapeutic strategies by targeting potassium ion channels in cancer cells. Experienced Professor with a …
Web14 apr. 2024 · BackgroundAs a common cancer with high incidence rate and mortality, colorectal cancer (CRC) is seriously threatening human health. S-nitrosylation (SNO) proteins mediated by nitric oxide (NO) has important implications in the genesis, … literature review vs dissertationWebThe disturbance of ion homeostasis is a novel strategy for the acceleration of cell malfunctions. 9 The disturbed ion homeostasis typically elicits apoptotic activity by ion … literature review vs bibliographyWeb7 jan. 2003 · The total intracellular concentration of zinc and the intracellular concentration of the available ion are carefully controlled. The homeostasis of zinc is maintained by regulation of zinc uptake and elimination but also on the level of intracellular sequestration in zinc storing vesicles, so-called zincosomes, and by controlled nucleo-cytoplasmic … literature review versus systematic reviewWebStudies by our laboratory in airway epithelial cells show that Zn is co-localized with the precursor form of caspase-3, mitochondria and microtubules, suggesting this Zn is … literature review vs literary researchWebA description of the role calcium plays in apoptosis, focusing on the endoplasmic reticulum and mitochondria. Apoptosis is a highly regulated mechanism of cell death, essential in development and tissue homeostasis. Apoptosis can occur via the extrinsic pathway, with ligand binding to death receptors on the cell surface, or via an internal ... import from memory cardWeb1 aug. 2001 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J literature review vs secondary researchWeb18 feb. 2024 · Cell-free DNA (cfDNA) is evolving into a widely used prognostic and predictive biomarker, particularly in oncology. However, its versatile clinical use precedes a profound understanding of the underlying biology of cfDNA release. There is much evidence to suggest that cfDNA is mainly derived from dying (i.e., apoptotic) cells. However, … import from less